Director/PDMR Shareholding

GlaxoSmithKline PLC
06 July 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned person on 5 July 2006 of an increase in the notional
allocation of Ordinary Share ADRs on 30 June 2006 at a price of $55.80 per
share:-

Dr M Slaoui                           5

The Administrators of the Plan further notified GlaxoSmithKline plc and the
under-mentioned person on 5 July 2006 of a decrease in the notional allocation
of Ordinary Share ADRs on 30 June 2006 at a price of $55.80 per share:-

Dr R Greig                            2

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(a).


S M Bicknell

Company Secretary

6 July 2006


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