Director/PDMR Shareholding

GlaxoSmithKline PLC
27 February 2007

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of:

•         Directors and Persons Discharging Managerial Responsibility in the
Ordinary Shares of GlaxoSmithKline plc in respect of the undermentioned persons
arising from the sale of Ordinary Shares at a price of £14.37 per Ordinary Share
on 27 February 2007 to meet their tax liabilities following the vesting of a
Performance Share Plan award:

Mr J S Heslop               1,025
Dr M M Slaoui               740
Mr J Clarke                 2,870
Mr D Learmouth              615

•         Persons Discharging Managerial Responsibility in the American
Depositary Shares (ADSs) of GlaxoSmithKline plc in respect of the undermentioned
person arising from the sale of ADSs at a price of $56.45 per ADS on 27 February
2007 to meet their tax liabilities following the vesting of a Performance Share
Plan award:

Mr W Louv                   325

The Company, Directors, Persons Discharging Managerial Responsibility and
Connected Persons were advised of these transactions on 27 February 2007.

•         Dr M M Slaoui as a result of the grant of options and an award to his
spouse, who is also employed by the company.  Dr Slaoui's wife received the
following awards:

Award under                                                  ADSs
GlaxoSmithKline Performance Share Plan (PSP)                 1,570
GlaxoSmithKline Share Option Plan (Option Plan)              3,570
GlaxoSmithKline Share Value Plan (SVP)                       890

The award of share options was made at a subscription price of $58.00 per ADS.

The Company and Dr Slaoui's wife were advised of these transactions on 26
February 2007.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(a).

S M Bicknell
Company Secretary

27 February 2007


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