Director/PDMR Shareholding

GlaxoSmithKline PLC
28 February 2007




   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares and Ordinary Share ADRs ("ADRs") of GlaxoSmithKline plc.


   22 February 2007              Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), transferred
                                 5,054 Ordinary Shares in the Company to participants in the
                                 SmithKline Beecham Employee Share Option Plan 1991.


   23 February 2007              The GSK Trust transferred 46,290 Ordinary Shares in the Company
                                 to participants in the SmithKline Beecham Employee Share Option
                                 Plan 1991.


   26 February 2007              The GSK Trust further transferred 11,960 Ordinary Shares in the
                                 Company to participants in the SmithKline Beecham Employee
                                 Share Option Plan 1991.



The Company was advised of these transactions on 27 February 2007.


   27 February 2007              Abacus Corporate Trustees Limited, as trustee of the
                                 GlaxoSmithKline (US) Trust, ("the GSK US Trust"), sold 325 ADRs
                                 at a price of $56.45 per ADR on behalf of participants in the
                                 GlaxoSmithKline Performance Share Plan.


                                 The GSK US Trust transferred 675 ADRs of GlaxoSmithKline plc to
                                 participants in the GlaxoSmithKline Performance Share Plan.


                                 Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), transferred
                                 28,752 Ordinary Shares in the Company to participants in the
                                 SmithKline Beecham Employee Share Option Plan 1991.


                                 The GSK Trust sold 5,250 Ordinary Shares in the Company at a
                                 price £14.37 on behalf of participants in the GlaxoSmithKline
                                 Performance Share Plan.


                                 The GSK Trust transferred 8,250 Ordinary Shares of
                                 GlaxoSmithKline plc to participants in the GlaxoSmithKline
                                 Performance Share Plan.



The Company was advised of these transactions on 28 February 2007.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr M M Slaoui
and Mr J S Heslop are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Dr M M Slaoui
are therefore interested in the shares held in the GSK US Trust from time to
time in the same way as other employees or former employees of SmithKline
Beecham Corporation and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).




S M Bicknell
Company Secretary



28 February 2007


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