Director/PDMR Shareholding

GlaxoSmithKline PLC
24 February 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Persons Discharging
Managerial Responsibility in the Ordinary Shares of GlaxoSmithKline plc in
respect of the undermentioned persons arising from the sale of Ordinary Shares
at a price of £14.65 per Ordinary Share on 23 February 2006 to meet their tax
liabilities following the vesting of a Performance Share Plan award:


Mr R Bondy                    6,150
Mr J Clarke                   2,870
Mr M Dunoyer                  1,435
Dr D Pulman                   3,245
Mr C Viehbacher               4,868
Mr A Witty                    1,435
Mrs J Younger                 820


I give below details of changes in the interests of Persons Discharging
Managerial Responsibility in the American Depositary Shares (ADSs) of
GlaxoSmithKline plc in respect of the undermentioned persons arising from the
sale of ADSs at a price of $51.3499 per ADS on 23 February 2006 to meet their
tax liabilities following the vesting of a Performance Share Plan award:


Dr F Calhoun                  1,670
Dr R Greig                    500


The Company was advised of these transactions on 23 February 2006.


This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(a).


S M Bicknell
Company Secretary

24 February 2006


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