Director/PDMR Shareholding

GlaxoSmithKline PLC
28 February 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 28 February 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 24 February 2006 at a price of
$51.10 per share:-

Dr J P Garnier                                                         53
Mr F Calhoun                                                           19
Dr R Greig                                                             21
Mr D Phelan                                                            25
Dr D Pulman                                                            6
Mr D Stout                                                             44
Mr C Viehbacher                                                        8
Dr T Yamada                                                            10


This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).


S M Bicknell
Company Secretary

28 February 2006




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