Director/PDMR Shareholding

GlaxoSmithKline PLC
03 November 2005


                              Director's Interests

I give below details of changes in interests in the Ordinary shares of
GlaxoSmithKline plc in respect of the under-mentioned Person Discharging
Managerial Responsibility:-

Mr R Bondy                    Exercise of nil-price options on 1 November 2005 
                              over 2,094 Ordinary shares granted on 
                              15 February 2002 under the SmithKline Beecham 
                              Mid-Term Incentive Plan ("the MTIP"), resulting 
                              from the deferral of an award made under the
                              MTIP on 23 November 1998.

                              Exercise of nil-price options on 1 November 2005 
                              over 2,094 Ordinary shares granted on 
                              13 February 2003 under the MTIP, resulting from 
                              the deferral of an award made under the MTIP on 
                              24 November 1999.

                              Sale of 1,718 Ordinary shares at a price of 
                              £14.6636 per share.

The Company was advised of these transactions on 3 November 2005.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(a).

S M Bicknell
Company Secretary

3 November 2005




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