Director/PDMR Shareholding

GlaxoSmithKline PLC
07 November 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 7 November 2005 of an increase in the
notional allocation of Ordinary Share ADRs on 3 November 2005 at a price of
$52.43 per share:-

Dr J P Garnier                                                         34
Dr T Yamada                                                            12
Dr W Calhoun                                                           6
Mr D Phelan                                                            108
Dr D Pulman                                                            1
Mr D Stout                                                             16
Mr C Viehbacher                                                        2
Mr J Ziegler                                                           5
Dr R Greig                                                             48


This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).


S M Bicknell
Company Secretary
7 November 2005


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