Director/PDMR Shareholding

GlaxoSmithKline PLC
28 November 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

     The Administrators of the GlaxoSmithKline US Retirement Savings 
     Plan ("the Plan") notified GlaxoSmithKline plc on 27 November 2006, 
     that as a result of a movement in the fund on 23 November 2006, 
     the number of Ordinary Share ADRs held by the fund had changed 
     from 17,444,497 to 17,429,386 at an average price of $52.00

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr M M Slaoui are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

28 November 2006


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