Director/PDMR Shareholding

GlaxoSmithKline PLC
10 March 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.
                         
   8 March 2006          Abacus (GSK) Trustees Limited, as trustee of the
                         GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                         transferred 479,591 Ordinary Shares in the Company 
                         to participants in the SmithKline Beecham Employee 
                         Share Option Plan 1991.

   9 March 2006          Abacus (GSK) Trustees Limited, as trustee of the 
                         GSK Trust, transferred 654,596 Ordinary Shares 
                         in the Company to participants in the SmithKline 
                         Beecham Employee Share Option Plan 1991.


The Company was advised of these transactions on 10 March 2006.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary

10 March 2006


                      This information is provided by RNS
            The company news service from the London Stock Exchange       DSDBLFFQXBLBBL