Director/PDMR Shareholding

GlaxoSmithKline PLC
10 March 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc in respect of the under-mentioned persons arising
from the purchase of Ordinary Shares at a price of £15.67 per Ordinary Share on
9 March 2006 through the Company's ShareReward Plan ("the Plan") which the
under-mentioned persons entered on 5 October 2001:

                         
Mr J S Heslop            Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mr R Bondy               Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mr A P Witty             Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)
                         
Mrs J V Younger          Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

The Company and the above-mentioned persons were advised of this information on
10 March 2006.


This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).


S M Bicknell
Company Secretary

10 March 2006


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