Director/PDMR Shareholding

GlaxoSmithKline PLC
14 March 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 13 March 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 10 March 2006 at a price of $54.40
per share:-

Dr T Yamada                                                            35
Dr F Calhoun                                                           172
Mr D Phelan                                                            159
Dr D Pulman                                                            55
Mr D Stout                                                             127
Mr C Viehbacher                                                        51
Dr R Greig                                                             169

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

14 March 2006




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