Director/PDMR Shareholding

GlaxoSmithKline PLC
08 August 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


04 August 2005             The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 08 August 2005 that 274 Ordinary shares in the
                           Company had been sold on 04 August 2005 on behalf of a participant in the
                           GlaxoSmithKline Annual Investment Plan at a price of £13.4036

                           The Trust also notified the Company on 08 August 2005 that 895 Ordinary shares
                           had been transferred from the Trust to a participant in the GlaxoSmithKline
                           Annual Investment Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell
Company Secretary

08 August 2005


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