Director/PDMR Shareholding

GlaxoSmithKline PLC
24 March 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

          The Administrators of the GlaxoSmithKline US Retirement 
          Savings Plan ("the Plan") notified GlaxoSmithKline plc on 
          20 March 2006, that as a result of a movement in the fund 
          on 16 March 2006, the number of Ordinary Share ADRs held by 
          the fund had changed from 17,734,613 to 17,624,275 at an 
          average price of $54.40

          The Administrators of the Plan notified GlaxoSmithKline plc 
          on 24 March 2006, that as a result of a movement in the fund 
          on 23 March 2006, the number of Ordinary Share ADRs held by 
          the fund had changed from 17,624,275 to 17,561,959 at
          an average price of $54.52

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4 R(1)(b).


S M Bicknell
Company Secretary

24 March 2006


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