Director/PDMR Shareholding

GlaxoSmithKline PLC 27 March 2006 Notification of Transactions of Directors, Persons Discharging Managerial Responsibility or Connected Persons I give below details of changes in the interests of Directors, Persons Discharging Managerial Responsibility or Connected Persons in the Ordinary Shares of GlaxoSmithKline plc. 20 March 2006 The Administrators of the SmithKline Beecham Employee Benefit Trust ("the Trust") notified the Company on 27 March 2006 that 782 Ordinary shares in the Company had been sold on 20 March 2006 on behalf of a participant in the SmithKline Beecham Bonus Investment Plan at a price of £15.37. 20 March 2006 The Trust also notified the Company on 27 March that 2,567 Ordinary shares had been transferred on 20 March 2006 from the Trust to a participant in the SmithKline Beecham Bonus Investment Plan. 20 March 2006 The Trust notified the Company on 27 March 2006 that 184,233 Ordinary shares in the Company had been purchased on 20 March 2006 on behalf of participants in the GlaxoSmithKline Annual Investment Plan at a price of £15.46. 21 March 2006 The Trust also notified the Company on 27 March 2006 that 9,175 Ordinary shares had been transferred on 21 March 2006 from the Trust to a participant in the GlaxoSmithKline Annual Investment Plan. The Trust is a discretionary fund of which all non US employees or former employees of GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. One of the Company's directors, Mr J Heslop is therefore interested in the shares held in the fund from time to time in the same way as other non US employees or former employees of GlaxoSmithKline plc and its subsidiaries. This notification relates to a transaction notified in accordance with Disclosure Rule 3.1.4R (1) (b). S M Bicknell Company Secretary 27 March 2006 This information is provided by RNS The company news service from the London Stock Exchange RDSQDLFLQXBXBBQ

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