Director/PDMR Shareholding

GlaxoSmithKline PLC
27 March 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




20 March 2006              The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 27 March 2006 that 782 Ordinary shares in the
                           Company had been sold on 20 March 2006 on behalf of a participant in the
                           SmithKline Beecham Bonus Investment Plan at a price of £15.37.



20 March 2006              The Trust also notified the Company on 27 March that 2,567 Ordinary shares had
                           been transferred on 20 March 2006 from the Trust to a participant in the
                           SmithKline Beecham Bonus Investment Plan.





20 March 2006              The Trust notified the Company on 27 March 2006 that 184,233 Ordinary shares
                           in the Company had been purchased on 20 March 2006 on behalf of participants
                           in the GlaxoSmithKline Annual Investment Plan at a price of £15.46.



21 March 2006              The Trust also notified the Company on 27 March 2006 that 9,175 Ordinary
                           shares had been transferred on 21 March 2006 from the Trust to a participant
                           in the GlaxoSmithKline Annual Investment Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R (1) (b).



S M Bicknell
Company Secretary


27 March 2006





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