Director/PDMR Shareholding

GlaxoSmithKline PLC
05 December 2005






   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the
Plan") notified GlaxoSmithKline plc on 5 December 2005, that as a result of a
movement in the fund on 1 December 2005, the number of Ordinary Share ADRs held
by the fund had changed from18,440,842 to 18,416,461 at an average price of
$50.45





The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R (1) (b).



S M Bicknell

Company Secretary



5 December 2005






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