Director/PDMR Shareholding

GlaxoSmithKline PLC
08 December 2005




   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons





I give below details of changes in interests in the American Depositary Shares
(ADSs) of GlaxoSmithKline plc in respect of the under-mentioned Director:-




Dr T Yamada                   Exercise of options over 74,868 ADSs granted on 25 March 1996, which would
                              if not exercised have lapsed on 25 March 2006, under the SmithKline Beecham
                              US 1991 Share Option Plan at a price of $22.36494 per ADS, followed by the
                              sale of the resulting ADSs.  These exercises and sales took place in two
                              tranches:



                              16,400 ADSs on 6 December 2005 at an average price of $50.52 per share.  The
                              Company was advised of these transactions on 7 December 2005.



                              58,468 ADSs on 7 December 2005 at an average price of $50.1035 per share.
                              The Company was advised of these transactions on 8 December 2005.



                              Dr Yamada's total shareholding in the Company remains 72,805 ADSs.



                              Under the Company's share ownership requirements executive directors,
                              including Dr Yamada, are required to hold a shareholding in the Company to
                              the value of at least three times their annual base salary.  Dr Yamada's
                              total shareholding is currently equivalent to more than four and a half
                              times his base salary.









This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell

Company Secretary



8 December 2005


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