Director/PDMR Shareholding

GlaxoSmithKline PLC
10 August 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc in respect of the undermentioned person(s) arising
from the purchase of Ordinary Shares at a price of £13.24 per Ordinary Share on
09 August 2005 through the Company's ShareReward Plan ("the Plan") which the
undermentioned persons entered on 5 October 2001:

Mr J S Heslop     Acquisition of 9 Ordinary Shares under the partnership element 
                  of the Plan (personal contribution)
                  Acquisition of 9 Ordinary Shares under the matching element of 
                  the Plan (Company contribution)
Mr R M Bondy      Acquisition of 9 Ordinary Shares under the partnership element 
                  of the Plan (personal contribution)
                  Acquisition of 9 Ordinary Shares under the matching element of 
                  the Plan (Company contribution)
Mr A P Witty      Acquisition of 9 Ordinary Shares under the partnership element 
                  of the Plan (personal contribution)
                  Acquisition of 9 Ordinary Shares under the matching element of 
                  the Plan (Company contribution)
Mrs J V Younger   Acquisition of 9 Ordinary Shares under the partnership element 
                  of the Plan (personal contribution)
                  Acquisition of 9 Ordinary Shares under the matching element of 
                  the Plan (Company contribution)

The above named persons and the Company were advised of this information on 10
August 2005.

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

10 August 2005




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