Director/PDMR Shareholding

GlaxoSmithKline PLC
16 August 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 16 August 2005 of increases in the
notional allocation of Ordinary Share ADRs as follows:-

As a result of movement in the fund on 04 August 2005 at a price of
$47.93 per ADR
Dr J P Garnier                                                         46
Dr T Yamada                                                            15
Mr W Calhoun                                                           7
Mr D Phelan                                                            143
Dr D Pulman                                                            2
Mr D Stout                                                             22
Mr C Viehbacher                                                        2
Mr J Ziegler                                                           6
Mr R Greig                                                             52
As a result of movement in the fund on 12 August 2005 at a price of
$47.88 per ADR
Mr R Greig                                                             3

This notification relates to a transaction notified in accordance with
Disclosure Rules

3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell

Company Secretary

16 August 2005


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