Director/PDMR Shareholding

GlaxoSmithKline PLC 22 August 2005 Notification of Transactions of Directors, Persons Discharging Managerial Responsibility or Connected Persons I give below details of changes in the interests of Directors, Persons Discharging Managerial Responsibility or Connected Persons in the Ordinary Shares of GlaxoSmithKline plc notified to the Company on 15 August 2005 and confirmed on 19 August 2005. 09 August 2005 The Administrators of the SmithKline Beecham Employee Benefit Trust ("the Trust") notified the Company that 4,746 Ordinary shares in the Company had been transferred from the Trust to a participant in the GlaxoSmithKline Annual Investment Plan. 10 August 2005 The Trust also notified the Company that 1,331 Ordinary shares in the Company had been transferred from the Trust to a participant in the GlaxoSmithKline Annual Investment Plan. 12 August 2005 The Trust also notified the Company that 3,486 Ordinary shares in the Company had been transferred from the Trust to a participant in the GlaxoSmithKline Annual Investment Plan. The Trust is a discretionary fund of which all non US employees or former employees of GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. One of the Company's directors, Mr J Heslop is therefore interested in the shares held in the fund from time to time in the same way as other non US employees or former employees of GlaxoSmithKline plc and its subsidiaries. This notification relates to a transaction notified in accordance with Disclosure Rule 3.1.4R(1)(b). S M Bicknell Company Secretary 22 August 2005 This information is provided by RNS The company news service from the London Stock Exchange

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