Director/PDMR Shareholding

GlaxoSmithKline PLC
22 August 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc notified to the Company on 15 August 2005 and
confirmed on 19 August 2005.

                    
09 August 2005      The Administrators of the SmithKline Beecham Employee 
                    Benefit Trust ("the Trust") notified the Company that 
                    4,746 Ordinary shares in the Company had been transferred 
                    from the Trust to a participant in the GlaxoSmithKline 
                    Annual Investment Plan.

10 August 2005      The Trust also notified the Company that 1,331 Ordinary 
                    shares in the Company had been transferred from the Trust 
                    to a participant in the GlaxoSmithKline Annual 
                    Investment Plan.

12 August 2005      The Trust also notified the Company that 3,486 Ordinary 
                    shares in the Company had been transferred from the Trust 
                    to a participant in the GlaxoSmithKline Annual Investment 
                    Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

22 August 2005


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