Director Shareholding

GlaxoSmithKline PLC 16 March 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 14 Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee March Trust ('the Trust'), transferred 27,504 Ordinary Shares in the Company to 2001 participants of the Glaxo Wellcome 1999 Share Option Plan, Glaxo Wellcome Long Term Incentive Plan, Glaxo Wellcome 1999 Long Term Incentive Plan and the Glaxo Wellcome International Share Option Scheme. The Trust also purchased 290,027 Ordinary shares in the Company at a price of £17.582819 per share. The Company was advised of this transaction on 15 March 2001. The Trust is a discretionary trust of which all employees or former employees of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes and John Coombe, as directors of Glaxo Wellcome plc, are therefore interested in the shares held in the Trust from time to time in the same way as other employees or former employees of Glaxo Wellcome plc and its subsidiaries. S M Bicknell Company Secretary 16 March 2001

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