Director Shareholding

GlaxoSmithKline PLC
28 December 2000


                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

28th     Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
December Employee Trust ('the Trust'), transferred 146,564 Ordinary Shares in
2000     the Company to participants of the Glaxo Wellcome Annual Incentive
         Plan and the Glaxo Wellcome Long Term Incentive Plan and sold 96,628
         Ordinary Shares in the Company as a result of vesting of shares under
         the Glaxo Wellcome Annual Incentive Plan and the Glaxo Wellcome Long
         Term Incentive Plan on the 27th December 2000.

The Company was advised of this transaction on 28th December 2000.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore, interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and it's subsidiaries.





S M Bicknell

Company Secretary



28th December 2000