Director Shareholding

GlaxoSmithKline PLC
1 March 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

28 February 2001    Abacus (GW) Trustees Limited, as trustee of The Glaxo 
                    Wellcome Employee Trust ('the Trust'), transferred 101,101 
                    Ordinary Shares in the Company to participants of the Glaxo 
                    Wellcome International Share Option Scheme and the Glaxo 
                    Wellcome 1999 Share Option Plan. The Trust also sold 18,686 
                    Ordinary shares in the Company at a price of £19.27 per 
                    share.

The Company was advised of this transaction on 1 March 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.


S M Bicknell

Company Secretary


1 March 2001