Director Shareholding

GlaxoSmithKline PLC
16 February 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

15       Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
February Employee Trust ('the Trust'), transferred 5,668 Ordinary Shares in the
2001     Company to participants of the Glaxo Wellcome International Share
         Option Scheme, Glaxo Wellcome UK Share Option Scheme and the Glaxo
         Wellcome 1999 Share Option Plan.




The Company was advised of this transaction on 16 February 2001.




The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.






S M Bicknell

Company Secretary




16 February 2001