Director Shareholding

GlaxoSmithKline PLC
27 April 2001


                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

25 April 2001   Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome 
                Employee Trust transferred 4,950 Ordinary Shares in the Company 
                to participants of the Glaxo Wellcome International Share Option

                Scheme.

The Company was advised of this transaction 26 April 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary


27 April 2001