Director Shareholding

GlaxoSmithKline PLC
22 February 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

21       Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
February Employee Trust ('the Trust'), transferred 2,130 Ordinary Shares in the
2001     Company to participants of the Glaxo Wellcome International Share
         Option Scheme and the Glaxo Wellcome 1999 Share Option Plan.


The Company was advised of this transaction on 22 February 2001.


The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.


S M Bicknell

Company Secretary


22 February 2001