Director Shareholding

GlaxoSmithKline PLC
27 March 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


23 March 2001   The Administrators of the SmithKline Beecham Employee Share 
                Ownership Trust ('the ESOT') notified the Company on the 26 
                March 2001, that on 23 March 2001, 4,615 Ordinary shares had 
                been transferred from the ESOT to participants of the SmithKline

                Beecham 1991 Share Option Plan and that 42,452 Ordinary Shares 
                in the Company had been transferred by the ESOT to participants 
                of the SmithKline Beecham Bonus Investment Plan.

The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier, as a director of SmithKline
Beecham plc, is therefore, interested in the shares held in the fund from time
to time in the same way as other employees or former employees of SmithKline
Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary


27 March 2001