Director Shareholding

GlaxoSmithKline PLC
6 February 2001

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

5th      The Administrators of the SmithKline Beecham Employee Share Ownership
February Trust ('the ESOT') notified the Company on the 5th February 2001, that
2001     45,496 Ordinary shares of 25p each had been transferred from the ESOT
         to participants of the SmithKline Beecham 1991 Share Option Plan.


The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier, as a director of SmithKline
Beecham plc, is therefore, interested in the shares held in the fund from time
to time in the same way as other employees or former employees of SmithKline
Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary


6th February 2001