Director Shareholding

GlaxoSmithKline PLC 5 April 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 4 Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee April Trust ('the Trust'), transferred 5,857 Ordinary Shares in the Company to 2001 participants of the Glaxo Wellcome 1999 Share Option Plan, the Glaxo Wellcome UK Share Option Scheme and the Glaxo Wellcome International Share Option Scheme. The Company was advised of this transaction 5 April 2001. The Trust is a discretionary trust of which all employees or former employees of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes and John Coombe are therefore interested in the shares held in the Trust from time to time in the same way as other employees or former employees of Glaxo Wellcome plc and its subsidiaries. S M Bicknell Company Secretary 5 April 2001

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