Director Shareholding

GlaxoSmithKline PLC
22 May 2001

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


18 May Trust     The Administrators of the SmithKline Beecham Employee Share 
                 Ownership ('the ESOT') notified the Company on the 21 May 2001,

                 that 2001 1,620,632 Ordinary shares had been transferred from 
                 the ESOT to participants of the SmithKline Beecham 1991 Share 
                 Option Plan.

The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.



S M Bicknell

Company Secretary


22 May 2001