Director Shareholding

GlaxoSmithKline PLC
23 May 2001


                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

22      Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
May     Trust ('the Trust'), transferred 1,155 Ordinary Shares in the Company to
2001    participants of the Glaxo Wellcome International Share Option Scheme and
        the Glaxo Wellcome 1999 Share Option Plan.


The Company was advised of these transactions on 23 May 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary

23 May 2001