Director Shareholding

GlaxoSmithKline PLC
8 May 2001

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

4    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
May  Trust ('the Trust'), transferred 13,798 Ordinary Shares in the Company to
2001 participants of the Glaxo Wellcome 1999 Share Option Plan and the Glaxo
     Wellcome International Share Option Scheme. The Trust also sold 7,033
     Ordinary shares in the Company at £18.29 per share.

The Company was advised of these transactions on 8 May 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.

S M Bicknell

Company Secretary

8 May 2001