Director Shareholding

GlaxoSmithKline PLC
14 May 2001

                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

11 May Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
2001   Trust ('the Trust'), sold 32,241 Ordinary Shares in the Company at a
       price of £19.52.


The Company was advised of these transactions on 14 May 2001.


The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.

S M Bicknell

Company Secretary


14 May 2001