Director Shareholding

GlaxoSmithKline PLC
30 March 2001





                             Directors' Interests


I give below details of changes in the directors' interests in the Ordinary
Shares and American Depositary Shares (ADSs) of GlaxoSmithKline plc.


On 29 March 2001, under the Rules of the GlaxoSmithKline Performance Share
Plan, Target Awards were granted over Ordinary Shares and ADSs in the Company
to the directors listed below:

                  Ordinary Shares        American Depository Shares
Dr JP Garnier                            70,000

Mr J D Coombe     40,000




On the same day, options to acquire the Company's Shares and ADSs were granted
under the GlaxoSmithKline Share Option Plan to the directors listed below:

           Ordinary     Subscription Price American Depository   Subscription
           Shares                          Shares                Price
Dr JP                                      450,000               $51.30
Garnier

Mr J D     290,000      £17.93
Coombe


Under the terms of the GlaxoSmithKline Performance Share Plan (which was
approved by Shareholders on 31 July 2000), Target Awards are granted annually
to eligible executives, designating a number of Shares/ADSs that may be
awarded, dependent upon the Company's performance over a three year
measurement period. The three year measurement period for the Target Awards
granted on 29 March 2001 commenced on 1 January 2001 and ends on 31 December
2003.


The grant of options is made under the GlaxoSmithKline Share Option Plan which
was approved by Shareholders on 31st July 2000. A performance condition has
been set for the vesting of the options granted to the above directors.


S M Bicknell

Company Secretary


30 March 2001