Director Shareholding

GlaxoSmithKline PLC
1 June 2001


                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


31 May 2001 The Administrators of the SmithKline Beecham US Retirement Savings 
            Plan ('the Plan') notified GlaxoSmithKline plc on the 1 June 2001, 
            that as a result of movement in the fund on the 31 May 2001, the 
            number of Ordinary share ADRs held by the fund had decreased from 
            17,389,046 to 17,328,354 at an average price of $54.6900.

The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary

1 June 2001