Director Shareholding

GlaxoSmithKline PLC
7 August 2001



                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


3 August 2001   The Administrators of the SmithKline Beecham Employee Share     
                Ownership Trust ('the ESOT') notified the Company on the 6      
                August 2001, that 576,836 Ordinary Shares had been transferred  
                from the ESOT to participants of the SmithKline Beecham 1991    
                Share Option Plan.

The company was informed of these transactions on 6 August 2001.

The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.

S M Bicknell

Company Secretary

7 August 2001