Director Shareholding

GlaxoSmithKline PLC
26 June 2001

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

25    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
June  Trust ('the Trust'), transferred 145,557 Ordinary Shares in the Company
2001  to participants of the Glaxo Wellcome 1999 Share Option Plan, The Glaxo
      Wellcome UK Share Option Scheme and the Glaxo Wellcome International
      Share Option Scheme.

The Company was advised of this transaction on 26 June 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary

26 June 2001