Director Shareholding

GlaxoSmithKline PLC
17 August 2001



                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

16 August 2001      Abacus (GW) Trustees Limited, as trustee of The Glaxo 
                    Wellcome Employee Trust ('the Trust'), transferred 439      
                    Ordinary Shares in the Company to participants of the Glaxo 
                    Wellcome UK Share Option Scheme.


The Company was advised of this transaction on 17 August 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary


17 August 2001