Director Shareholding

GlaxoSmithKline PLC
28 August 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

24       Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
August   Trust ('the Trust'), transferred 11,042 Ordinary Shares in the Company
2001     to participants of the Glaxo Wellcome International Share Option Scheme
         and the Glaxo Wellcome Long Term Incentive Plan. The Trust also sold
         3,908 Ordinary Shares in the Company at £18.67 per share.





The Company was advised of these transactions on 28 August 2001.




The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.






S M Bicknell

Company Secretary




28 August 2001