Director Shareholding

GlaxoSmithKline PLC
3 September 2001

                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

30 August 2001    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
                  Employee Trust ('the Trust'), purchased 600,000 Ordinary 
                  Shares in the Company at a price of £18.270853 per share.

31 August 2001    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
                  Employee Trust ('the Trust'), purchased 37,450 Ordinary Shares
                  in the Company at a price of £18.276662 per share.

31 August 2001    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
                  Employee Trust ('the Trust'), purchased 223,396 Ordinary 
                  Shares in the Company at a price of £18.278516 per share.
     
31 August 2001    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
                  Employee Trust ('the Trust'), transferred 5,616 Ordinary 
                  Shares in the Company to participants of the Glaxo Wellcome UK
                  Share Option Scheme and the Glaxo Wellcome International Share
                  Option Scheme.

The Company was advised of these transactions on 3 September 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary


3 September 2001