Director Shareholding

GlaxoSmithKline PLC
5 October 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


4       The Administrators of the SmithKline Beecham US Retirement Savings Plan
October ('the Plan') notified GlaxoSmithKline plc on the 5 October 2001, that
2001    as a result of movement in the fund on the 4 October 2001, the number
        of Ordinary Share ADRs held by the fund had decreased from 18,440,404
        to 18,389,403 at an average price of $55.9000

The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.



S M Bicknell

Company Secretary

5 October 2001