Director Shareholding

GlaxoSmithKline PLC
24 September 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


21         The Administrators of the SmithKline Beecham Employee Share Ownership
September  Trust ('the ESOT') notified the Company on the 24 September 2001,
2001       that 120,899 Ordinary shares had been transferred from the ESOT to
           participants of the SmithKline Beecham 1991 Share Option Plan.

The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.





S M Bicknell

Company Secretary

24 September 2001