Director Shareholding

GlaxoSmithKline PLC
15 October 2001


                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

12        The Administrators of the SmithKline Beecham Employee Share Ownership
October   Trust ('the ESOT') notified the Company on the 15 October 2001, that
2001      180,614 Ordinary shares had been transferred from the ESOT to
          participants of the SmithKline Beecham 1991 Share Option Plan and 60
          Ordinary shares were purchased at a price of £19.37 per share for
          partipants of the SmithKline Beecham Unapproved Share Matching Plan.

The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary

15 October 2001