Director Shareholding

GlaxoSmithKline PLC
17 October 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


12       The Administrators of the SmithKline Beecham US Retirement Savings Plan
October  ('the Plan') notified GlaxoSmithKline plc on the 17 October 2001, that
2001     as a result of movement in the fund on the 12 October 2001, the number
         of Ordinary Share ADRs held by the fund had increased from 18,376,891
         to 18,409,951 at an average price of $56.2400

The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary


17 October 2001