Director Shareholding

GlaxoSmithKline PLC
22 October 2001



                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

19      Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
October Trust ('the Trust'), transferred 37,191 Ordinary Shares in the Company
2001    to participants of the Glaxo Wellcome UK Share Option Scheme, the Glaxo
        Wellcome 1999 Share Option Plan and the Glaxo Wellcome International
        Share Option Scheme.


The Company was advised of this transaction on 22 October 2001.

The Trust is a discretionary trust of which all employees or former employees
of GlaxoSmithKline Services plc (formerly Glaxo Wellcome plc) and its
subsidiaries are potential beneficiaries. Two of the Company's directors, Sir
Richard Sykes and John Coombe are therefore interested in the shares held in
the Trust from time to time in the same way as other employees or former
employees of GlaxoSmithKline Services plc and its subsidiaries.






S M Bicknell

Company Secretary

22 October 2001