Director Shareholding

GlaxoSmithKline PLC
22 January 2002


                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


18 January 2002   The Administrators of the SmithKline Beecham Employee Benefit 
                  Trust ('the Trust') notified the Company on the 21 January 
                  2002, that 22,537 Ordinary shares had been transferred from 
                  the Trust to participants of the SmithKline Beecham 1991 Share
                  Option Plan.

The Trust is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One of
the Company's directors, Dr J P Garnier is therefore, interested in the shares
held in the fund from time to time in the same way as other employees or former
employees of SmithKline Beecham plc and its subsidiaries.



S M Bicknell

Company Secretary


22 January 2002



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