Director Shareholding

GlaxoSmithKline PLC
30 November 2001



                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

29       Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
November Employee Trust ('the Trust'), purchased 725,600 Ordinary Shares in the
2001     Company at a price of £17.80 per share.



The Company was advised of this transaction on 30 November 2001.


The Trust is a discretionary trust of which all employees or former employees
of GlaxoSmithKline Services plc (formerly Glaxo Wellcome plc) and its
subsidiaries are potential beneficiaries. Two of the Company's directors, Sir
Richard Sykes and John Coombe are therefore interested in the shares held in
the Trust from time to time in the same way as other employees or former
employees of GlaxoSmithKline Services plc and its subsidiaries.



S M Bicknell

Company Secretary



30 November 2001