Director Shareholding

GlaxoSmithKline PLC
20 December 2001

                             Directors' Interests

I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned directors:

                                                                              
  Sir Richard Sykes      Beneficial interest in 12 Ordinary Shares purchased  
                         under a Personal Equity Plan on 17 December 2001 at  
                         £16.96. 
                                             
                         Lady Janet Sykes (wife); beneficial interest in 8    
                         Ordinary Shares purchased under a Personal Equity    
                         Plan on 17 December 2001 at £16.96.                  

  Mr J D Coombe          Beneficial interest in 7 Ordinary Shares purchased   
                         under a Personal Equity Plan on 17 December 2001 at  
                         £16.96.                                              

                         Mrs G A Coombe (wife); beneficial interest in 5      
                         Ordinary Shares purchased under a Personal Equity    
                         Plan on 17 December 2001 at £16.96.                  

  Sir Christopher Hogg   Beneficial interest in 20 Ordinary Shares purchased  
                         under a Personal Equity Plan on 17 December 2001 at  
                         £16.96.                                              

The Directors and the Company were advised of these transactions on 19
December 2001.

S M Bicknell
Company Secretary
20 December 2001