Director Shareholding

GlaxoSmithKline PLC
2 January 2002



                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

21         Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
December   Employee Trust ('the Trust'), transferred 74,074 Ordinary Shares in
2001       the Company to participants of the Glaxo Wellcome 1999 Share Option
           Plan and the Glaxo Wellcome International Share Option Scheme.




The Company was advised of this transaction on 24 December 2001.




The Trust is a discretionary trust of which all employees or former employees
of GlaxoSmithKline Services plc (formerly Glaxo Wellcome plc) and its
subsidiaries are potential beneficiaries. Two of the Company's directors, Sir
Richard Sykes and John Coombe are therefore interested in the shares held in
the Trust from time to time in the same way as other employees or former
employees of GlaxoSmithKline Services plc and its subsidiaries.



S M Bicknell

Company Secretary




2 January 2002