Director Shareholding

GlaxoSmithKline PLC
17 December 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


14 December 2001    The Trustees of the SmithKline Beecham Employee Benefit  
                    Trust ('the Trust') purchased 630,000 Ordinary Shares in 
                    the Company at a price of £17.3071220 per share.


The Company was advised of this transaction on the 17 December 2001


The Trust is a discretionary fund of which all employees or former employees
of SmithKline Beecham plc and its subsidiaries are potential beneficiaries.
One of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary


17 December 2001