Director Shareholding

GlaxoSmithKline PLC
18 December 2001

                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



14       The Administrators of the SmithKline Beecham Employee Benefit Trust
December ('the Trust') notified the Company on the 17 December 2001, that
2001     42,293 Ordinary shares had been transferred from the Trust to
         participants of the SmithKline Beecham 1991 Share Option Plan.



The Trust is a discretionary fund of which all employees or former employees
of SmithKline Beecham plc and its subsidiaries are potential beneficiaries.
One of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.



S M Bicknell

Company Secretary


18 December 2001